Um, so let's look ahead and see, uh, once, uh, we get, uh, some additional signal from Um, mucosal melanoma and uh ovarian cancer. Are there other tumors for which nyvolleukin may, uh, provide a role? Um, Uh, given, uh, my own feeling, which is that there are T cells recognizing virtually every cancer and it's part of the cancer biology. Um, uh, I would think virtually every cancer could potentially, uh, be benefited by inclusion of nembaleukin into a regimen, and it depends on Uh, what's broken in the immune response to cancer. Um, I used to give a lecture to the medical students here called Um, tumor immunology. And I used to illustrate, uh, the notion that there are many, many ways that tumors escape immune recognition with an old Paul Simon song called uh There Must be 50 Ways to Leave Your Lover, and They always laughed up until one year where they stopped laughing and it was because nobody knew the song anymore. But there are, there are many ways in which uh tumors can escape. Uh, but I think just as I mentioned at the very beginning, the TNF is a clear node in rheumatoid arthritis that we may not have perceived. Back in the beginning, uh, when we were cataloging all the cytokines and cells and chemokines involved with rheumatoid arthritis, I would say that in my estimation, based on where I sit and understand the biology, IL2 is a clear node. In the uh biology. Uh it is uh centrally important for T cell biology, not that you can't live without it. We've been able to knock out IL-2 and mouse models. They suffer from a Treg disease, uh, essentially autoimmunity after 6 months. But I believe that IL-2 is centrally important in tumor immunology and Either by luck or by Happenstance or by uh clever scheming, I think we have a molecule that at least seems to have threaded this difficult passageway between solo and Caribus between enhancing efficacy and and decreasing toxicity. And so, I believe that it's conceivable that Nealleukin could be combined not only with checkpoints as they currently doing, but with uh immune effectors, CAIS, till, uh potentially NK effectors. Um, as well as vaccines, as well as conventional chemotherapy and possibly radiation therapy. I'm enough of a Uh, T cell chauvinists to believe that whenever Conventional chemotherapy or radiation therapy works, or even surgery. It works because of an effective enabling and effective T cell response, and I believe that um it's conceivable to me from where I sit right now, that nevolleukin may also play that critical necessary role as a constituent of a uh multi. Trout or multi-agent therapy.
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